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NADPH in Erythrocyte Oxidative Control The predominant pathways of carbohydrate metabolism in the red blood cell (RBC) are glycolysis, the pentose phosphate pathway (PPP) and 2,3-bisphosphoglycerate (2,3-BPG) metabolism (refer to the Hemoglobin and Myoglobin page for review of the synthesis and role role of 2,3-BPG)